WP8 – Genetic factors influencing the response to the therapy in small population group trials
The major objective of WP8 is the development of new statistical models for prediction of the response to the therapy in small population group trials based on genetic factors and other covariates.
The main objectives to achieve are:
- Bayesian methods for identification of genetic pathways involved in the development of disease and the response to the therapy.
- Development and application of high dimensional model selection for identification of regulatory regions influencing detected pathways.
- Statistical model relating response to the therapy in small population group trials based on identified genetic factors and other covariates, as well as their interactions.