{"id":401,"date":"2013-09-06T12:06:54","date_gmt":"2013-09-06T10:06:54","guid":{"rendered":"http:\/\/www.ideal.rwth-aachen.de\/?page_id=401"},"modified":"2013-09-10T11:09:32","modified_gmt":"2013-09-10T09:09:32","slug":"inserm","status":"publish","type":"page","link":"https:\/\/www.ideal.rwth-aachen.de\/?page_id=401","title":{"rendered":"INSERM"},"content":{"rendered":"<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='inserm' class='avia-section main_color avia-section-default avia-shadow avia-bg-style-scroll   container_wrap fullsize' style = 'background-image: '  ><div class='container' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-401'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_fourth  flex_column_div first  \" ><div class='avia-image-container avia_animated_image avia_animate_when_almost_visible left-to-right av-styling-    avia-align-left '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><a href='http:\/\/www.biostat.fr' class='avia_image'   target=\"_blank\" ><img class='avia_image ' src='http:\/\/www.ideal.rwth-aachen.de\/wp-content\/uploads\/2013\/08\/logo-P7.png' alt='' title=''  itemprop=\"thumbnailUrl\"  \/><\/a><\/div><\/div><\/div><\/div><div class=\"flex_column av_three_fourth  flex_column_div   \" ><p><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h3    '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >French National Institute of Health and Medical Research<\/h3><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h3  blockquote modern-quote  '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Biostatistical Modelling and Pharmacometrics<\/h3><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n\t<div  class='av_promobox  avia-button-yes '>\t\t<div class='avia-promocontent'><\/p>\n<address>UMR 738<br \/>\nUniversit\u00e9 Paris Diderot<br \/>\nUFR de M\u00e9decine &#8211; site Bichat<br \/>\n16 rue Henri Huchard<br \/>\n75018 Paris<\/address>\n<p>\n<\/div><div class='avia-button-wrap avia-button-right '><a href='https:\/\/maps.google.de\/maps?q=16+rue+Henri+Huchard+75018+Paris'  class='avia-button   avia-icon_select-yes-left-icon avia-color-orange avia-size-small avia-position-right '  target=\"_blank\"   ><span class='avia_button_icon avia_button_icon_left ' aria-hidden='true' data-av_icon='\ue842' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >Google Maps<\/span><\/a><\/div>\t<\/div><br \/>\n<div style='padding-bottom:7px; ' class='av-special-heading av-special-heading-h5    '><h5 class='av-special-heading-tag '  itemprop=\"headline\"  >Our Staff<\/h5><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<div class='avia-data-table-wrap avia_responsive_table'><table class='avia-table avia-data-table avia-table-1  avia_pricing_default '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/Table\" ><tbody><tr class=''><td class=''>WP 5 &#8211; lead<\/td><th class='avia-desc-col'>Prof. France Mentre<\/th><td class=''>france.mentre@inserm.fr<\/td><td class=''><a href=\"http:\/\/cvscience.aviesan.fr\/cv\/788\/france-mentre\">Webpage<\/a><\/td><\/tr><\/tbody><\/table><\/div><style type='text\/css'>.avia-table-1 td:nth-of-type(1):before { content: 'WP 5 \u2013 lead'; } <\/style><\/p><\/div><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h3    '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >About<\/h3><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div>\n<p><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Founded in 1964, the <b>French National Institute of Health and Medical Research<\/b> (INSERM) is a public scientific and technological institute which operates under the joint authority of the French Ministry of Health and French Ministry of Research.<\/p>\n<p>As the only French public research institute to focus entirely on human health, in 2008 Inserm took on the responsibility for the strategic, scientific and operational coordination of biomedical research. This key role as coordinator comes naturally to Inserm thanks to the scientific quality of its teams and its ability to conduct translational research, from the laboratory to the patient\u2019s bed.\u00a0 From the outset, Institute has forged close partnerships with the other public and private research establishments as well as hospitals to fulfil its missions<b>. 80% of Inserm\u2019s 318 research units <\/b>are currently set up in university hospitals or cancer research centers.<\/p>\n<p>Our research group is located within the School of Medicine of University Paris Diderot and is funded by INSERM and University Paris Diderot. The title of our team is \u201cBiostatistical Modelling and Pharmacometrics\u201d (<a href=\"http:\/\/www.biostat.fr\/\">www.biostat.fr<\/a>) and Professor France Mentr\u00e9 is head of the team.<\/p>\n<p>We develop statistical methods for non-linear mixed effects models \u00a0which are used in pharmacometrics and model-based drug development. We apply them mainly for evaluation of anti-infective drugs in collaboration with colleagues.<\/p>\n<p>In this area of NLMEM, we are involved mainly on methods for design evaluation\/ optimisation, methods for model evaluation, methods for testing of genetic covariates, methods for estimation without linearisation. We developed the packages PFIM, npde and saemix in R used in academia and pharmaceutical industry.<\/p>\n<p><b>Main Project Tasks and Experiences related to the project: <\/b>Main methodological research areas of INSERM UMR 738: models and methods for therapeutic evaluation in chronic diseases are biostatistical modelling and pharmacometrics, exact estimation methods in non-linear mixed effects models, design optimisation in non-linear mixed effects models, model evaluation and model selection, covariate tests and pharmacogenetics. INSERM UMR 738 is fully responsible for the work package \u201cOptimal design in mixed models to analyse studies in small population groups\u201d.<\/p>\n<p><b>Key Personnel: <\/b><\/p>\n<p style=\"padding-left: 30px;\"><b>Professor France Mentr\u00e9<\/b> is part of the Innovative Medicines Initiative Joint Undertaking under grant agreement n\u00b0 115156, with financial contributions from the European Union&#8217;s Seventh Framework Programmemee (FP7\/2007-2013). In this project called \u201cDrug Disease Modelling Resources\u201d, she is member of the Work package responsible for developing new tools, especially in tasks for adaptive designs and model evaluation.<\/p>\n<p style=\"padding-left: 30px;\">Professor France Mentr\u00e9 is associate editor of the recently launched (2012) online journal of the Nature Publishing Group called \u201cPharmacometrics and System Pharmacology\u201d<\/p>\n<\/div><\/section>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":60,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-401","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=401"}],"version-history":[{"count":8,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/401\/revisions"}],"predecessor-version":[{"id":573,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/401\/revisions\/573"}],"up":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/60"}],"wp:attachment":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}