{"id":342,"date":"2013-09-06T11:13:29","date_gmt":"2013-09-06T09:13:29","guid":{"rendered":"http:\/\/www.ideal.rwth-aachen.de\/?page_id=342"},"modified":"2013-10-05T18:54:09","modified_gmt":"2013-10-05T16:54:09","slug":"wp-9-simulation","status":"publish","type":"page","link":"https:\/\/www.ideal.rwth-aachen.de\/?page_id=342","title":{"rendered":"WP 9 \u2013 Decision analysis"},"content":{"rendered":"<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_1' class='avia-section main_color avia-section-default avia-shadow avia-bg-style-scroll   container_wrap fullsize' style = 'background-image: '  ><div class='container' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-342'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_three_fourth  flex_column_div first  \" ><p><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h4    '><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >WP9 \u2013 Decision analysis in small population groups<\/h4><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>The central challenge in clinical medicine is to find the optimal treatment for each individual patient. There are a number of challenges, however, especially for small population groups. To help overcome these challenges, an analysis of stakeholder decisions is instrumental. Different decisions (by regulators, payers, physician and patient) are based on the results from confirmatory clinical trials. Regulatory and payer decision rules may have to be adjusted for rare diseases and personalised health care settings.<\/p>\n<p>We will therefore analyse the impact of different decision rules on e.g. expected total patient utility and optimal trial designs. Furthermore, we will consider the incentives for development of new treatments for small population groups.<\/p>\n<p>The goal is to improve the rational basis for decisions, and help align different stakeholder perspectives. This, we think, will increase the number of novel drugs for small population groups, and improve the patient\u2019s availability to optimally choose between different treatment options.<\/p>\n<\/div><\/section><\/p><\/div><div class=\"flex_column av_one_fourth  flex_column_div   \" ><p><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h4 meta-heading   '><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >Lead participant <\/h4><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<div class='avia-image-container avia_animated_image avia_animate_when_almost_visible right-to-left av-styling-    avia-align-center '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><a href='?page_id=420' class='avia_image'  ><img class='avia_image ' src='http:\/\/www.ideal.rwth-aachen.de\/wp-content\/uploads\/2013\/09\/team_chalmers.png' alt='' title='team_chalmers'  itemprop=\"thumbnailUrl\"  \/><\/a><\/div><\/div><\/div><\/p><\/div><div class=\"flex_column av_one_full  flex_column_div first  \" ><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":58,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-342","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/342","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=342"}],"version-history":[{"count":4,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/342\/revisions"}],"predecessor-version":[{"id":645,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/342\/revisions\/645"}],"up":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/58"}],"wp:attachment":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}