{"id":338,"date":"2013-09-06T11:12:17","date_gmt":"2013-09-06T09:12:17","guid":{"rendered":"http:\/\/www.ideal.rwth-aachen.de\/?page_id=338"},"modified":"2013-10-05T18:50:45","modified_gmt":"2013-10-05T16:50:45","slug":"wp-8-decision-analysis","status":"publish","type":"page","link":"https:\/\/www.ideal.rwth-aachen.de\/?page_id=338","title":{"rendered":"WP 8 \u2013 Genetic factors"},"content":{"rendered":"<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_1' class='avia-section main_color avia-section-default avia-shadow avia-bg-style-scroll   container_wrap fullsize' style = 'background-image: '  ><div class='container' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-338'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_three_fourth  flex_column_div first  \" ><p><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h4    '><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >WP8 \u2013 Genetic factors influencing the response to the therapy in small population group trials<\/h4><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>The major objective of WP8 is the development of new statistical models for prediction of the response to the therapy in small population group trials based on genetic factors and other covariates.<\/p>\n<p>The main objectives to achieve are:<\/p>\n<ul>\n<li>Bayesian methods for identification of genetic pathways involved in the development of disease and the response to the therapy.<\/li>\n<li>Development and application of high dimensional model selection for identification of regulatory regions influencing detected pathways.<\/li>\n<li>Statistical model relating response to the therapy in small population group trials based on identified genetic factors and other covariates, as well as their interactions.<\/li>\n<\/ul>\n<\/div><\/section><\/p><\/div><div class=\"flex_column av_one_fourth  flex_column_div   \" ><p><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h4 meta-heading   '><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >Lead participant <\/h4><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<div class='avia-image-container avia_animated_image avia_animate_when_almost_visible right-to-left av-styling-    avia-align-center '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><a href='?page_id=338' class='avia_image'  ><img class='avia_image ' src='http:\/\/www.ideal.rwth-aachen.de\/wp-content\/uploads\/2013\/09\/team_wroclaw.png' alt='' title='team_wroclaw'  itemprop=\"thumbnailUrl\"  \/><\/a><\/div><\/div><\/div><\/p><\/div><div class=\"flex_column av_one_full  flex_column_div first  \" ><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":58,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-338","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=338"}],"version-history":[{"count":5,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/338\/revisions"}],"predecessor-version":[{"id":643,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/338\/revisions\/643"}],"up":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/58"}],"wp:attachment":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}