{"id":331,"date":"2013-09-06T11:07:37","date_gmt":"2013-09-06T09:07:37","guid":{"rendered":"http:\/\/www.ideal.rwth-aachen.de\/?page_id=331"},"modified":"2013-09-10T10:57:51","modified_gmt":"2013-09-10T08:57:51","slug":"wp6-pharmacogenetics","status":"publish","type":"page","link":"https:\/\/www.ideal.rwth-aachen.de\/?page_id=331","title":{"rendered":"WP6 \u2013 Pharmacogenetics"},"content":{"rendered":"<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_1' class='avia-section main_color avia-section-default avia-shadow avia-bg-style-scroll   container_wrap fullsize' style = 'background-image: '  ><div class='container' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-331'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_three_fourth  flex_column_div first  \" ><p><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h4    '><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >WP6 \u2013 Design of pharmacogenetic small population group trials<br \/>\nincluding cross-over trials, n-of-1 trials and enrichment trials<\/h4><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Individual response to treatment is often poorly studied and understood. It is necessary to isolate the various components of variation: pure between patient, pure within patients and patient by treatment interaction. This work-package is particularly concerned with developing approaches to identifying such components.<\/p>\n<p>The following objectives will be met:<\/p>\n<ul>\n<li>Identification of conditions that have to be met for personalising therapy to be worthwhile, paying particular attention to so-called <i>theranostic<\/i> (combined diag<span style=\"text-decoration: underline;\">nostic<\/span> and <span style=\"text-decoration: underline;\">thera<\/span>peutic) approaches<\/li>\n<li>Development of practical and useable n-of-1 (or repeated cross-over) templates for those disease areas where repeated treatment of patients is possible<\/li>\n<li>Development of suitable approaches to analysing subgroups for those diseases where cross-over trials are not possible<\/li>\n<li>Establishing approaches to sample-size determination that take account of the value of information<\/li>\n<\/ul>\n<p>It is envisaged that each of the tasks will lead to a paper, which will include recommendations and guidance, and that tasks 1,2 and 4 will involve writing code that will be made publicly available.<\/p>\n<\/div><\/section><\/p><\/div><div class=\"flex_column av_one_fourth  flex_column_div   \" ><p><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h4 meta-heading   '><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >Lead participant <\/h4><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<div class='avia-image-container avia_animated_image avia_animate_when_almost_visible right-to-left av-styling-    avia-align-center '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><a href='?page_id=405' class='avia_image'  ><img class='avia_image ' src='http:\/\/www.ideal.rwth-aachen.de\/wp-content\/uploads\/2013\/08\/logo-crp-sante.gif' alt='' title=''  itemprop=\"thumbnailUrl\"  \/><\/a><\/div><\/div><\/div><\/p><\/div><div class=\"flex_column av_one_full  flex_column_div first  \" ><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":58,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-331","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=331"}],"version-history":[{"count":4,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/331\/revisions"}],"predecessor-version":[{"id":556,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/331\/revisions\/556"}],"up":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/58"}],"wp:attachment":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}