{"id":324,"date":"2013-09-06T11:05:54","date_gmt":"2013-09-06T09:05:54","guid":{"rendered":"http:\/\/www.ideal.rwth-aachen.de\/?page_id=324"},"modified":"2013-09-10T10:58:50","modified_gmt":"2013-09-10T08:58:50","slug":"wp5-optimal-design","status":"publish","type":"page","link":"https:\/\/www.ideal.rwth-aachen.de\/?page_id=324","title":{"rendered":"WP5 \u2013 Optimal design"},"content":{"rendered":"<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_1' class='avia-section main_color avia-section-default avia-shadow avia-bg-style-scroll   container_wrap fullsize' style = 'background-image: '  ><div class='container' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-324'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_three_fourth  flex_column_div first  \" ><p><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h4    '><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >WP5 \u2013 Optimal design in mixed models to analyse studies in small population groups<\/h4><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p>Non-linear mixed effects models are used in model-based drug development to analyse all longitudinal data obtained during clinical trials. This is especially promising in small group trials. Therefore, finding good design for these studies is important to get precise results and\/or good power especially when there are limitations on the sample size and on the number of sample\/visit per patient.<\/p>\n<p>Following our pioneer work in optimal design based on the Fisher Information Matrix for non-linear mixed effects models with continuous data, we wish to:<\/p>\n<ul>\n<li>Extend and evaluate this approach for longitudinal models with discrete data, repeated time to event and joint models<\/li>\n<li>Propose robust approaches with respect to parameter values as two-stage adaptive designs<\/li>\n<li>Propose robust approaches with respect to model uncertainty in design and analysis of pivotal trials analysed trough modelling<\/li>\n<\/ul>\n<p>The developments will be made freely available in software tools, for instance as extensions of PFIM in R.<\/p>\n<\/div><\/section><\/p><\/div><div class=\"flex_column av_one_fourth  flex_column_div   \" ><p><div style='padding-bottom:10px; ' class='av-special-heading av-special-heading-h4 meta-heading   '><h4 class='av-special-heading-tag '  itemprop=\"headline\"  >Lead participant <\/h4><div class='special-heading-border'><div class='special-heading-inner-border' ><\/div><\/div><\/div><br \/>\n<div class='avia-image-container avia_animated_image avia_animate_when_almost_visible right-to-left av-styling-    avia-align-center '  itemprop=\"ImageObject\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\"  ><div class='avia-image-container-inner'><div class='avia-image-overlay-wrap'><a href='?page_id=401' class='avia_image'  ><img class='avia_image ' src='http:\/\/www.ideal.rwth-aachen.de\/wp-content\/uploads\/2013\/08\/logo-P7.png' alt='' title=''  itemprop=\"thumbnailUrl\"  \/><\/a><\/div><\/div><\/div><\/p><\/div><div class=\"flex_column av_one_full  flex_column_div first  \" ><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":58,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-324","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=324"}],"version-history":[{"count":5,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/324\/revisions"}],"predecessor-version":[{"id":557,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/324\/revisions\/557"}],"up":[{"embeddable":true,"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=\/wp\/v2\/pages\/58"}],"wp:attachment":[{"href":"https:\/\/www.ideal.rwth-aachen.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}